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Bone Cancers

Our bone cancer program combines limb-salvage surgery innovation with targeted therapies for osteosarcoma, Ewing sarcoma, and chondrosarcoma.

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280+
Sarcoma cases managed annually
82%
Limb-salvage success rate
3,400+
Tissue bank specimens

Research Themes

1

Osteosarcoma Genomics

Whole-genome sequencing to identify copy number alterations and chromothripsis events driving chemoresistance in osteosarcoma.

2

Limb-Salvage Innovation

3D-printed custom prostheses and navigation-guided resection to maximise function after tumour removal.

3

Ewing Sarcoma Targeted Therapy

Evaluating IGF-1R inhibitors and EZH2 inhibitors as novel therapeutic approaches in relapsed Ewing sarcoma.

Clinical Trials

NCT06234517

Active

Regorafenib in Relapsed Osteosarcoma After First-Line Failure

PI: Dr. Mayilvahanan Bose

NCT06234518

Recruiting

3D-Printed Prosthesis vs Conventional Endoprosthesis in Limb Salvage

PI: Dr. Mayilvahanan Bose

Help Young Patients Beat Bone Cancer

Your support funds innovative limb-salvage surgery technologies and genomic research that give young bone cancer patients the best chance at a full, active life.

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